Canonical Question

Antihypertensive

V5 D7.iii Historical V4 G7.ii 4 appearances

Master answer

Class I – Phenylalkylamines:
- Verapamil
- Reduces HR, contractility and causes vasodilatation, decrease in cardiac contractility, heart rate, and both coronary and peripheral vascular tone.
Class II – Dihydropyridines:
- main effects are on vasodilatation
- 1st gen = nifedipine
- 2nd gen = felodipine, nimodipine
- 3rd gen = amlodipine
Class III – Benzothiazepines:
- diltiazem
- some reduction in HR and contractility, also causes vasodilatation, mild to moderate decrease in myocardial contraction, and decreases heart rate by decreasing both the automaticity of the SA node and the rate of conduction in the AV node.

Heart
- V-W Class 4 antiarrhythmic
- Decr SA node automaticity
- Decr AV node conductivity
- Vasodilation
- Negative inotropy
- reflex tachycardia
2) Vasculature
- Decr SVR and BP
- Decr Hypoxic pulmonary vasoconstriction
- Incr coronary and cerebral blood flow
3) Other
- Tocolytic
- NDMR potentiation.

Gladwin / JC 2021

Answer by Gladwin, JC

Exam	Exact wording	Relationship	Success
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