Canonical Question
Lignocaine Pharmacology
Master answer
Local Anaesthetics
- Local anaesthetic agents act via inhibition of voltage gated Na+ channels, by binding to the intracellular portion of the channel
- → Decreased Na influx
- → Inhibition of depolarization
- → Inhibition of action potential formation and propagation
- Local anaesthetics are formed by a hydrophobic and hydrophillic component, and are classified according to the linkage between the two, either amide or ester
- Amide Local Anaesthetics
- e.g. Lignocaine, ropivacaine, bupivacaine
- Metabolized by hepatic dealkylation by P450 enzymes
- Longer duration of action
- Ester Local Anaesthetics
- e.g. Procainamide, cocaine
- Metabolized by plasma esterases
- Shorter duration of action
Mooney / JC 2019
Pharmacology of Lignocaine
Exam appearances
| Exam | Exact wording | Relationship | Success |
|---|---|---|---|
| 2014A Q17 | Classify local anaesthetic agents and give examples. (30% of marks) Describe the pharmacology of lignocaine. (70% of marks) | historical_member | 71.00% |